Isolation Of Caffeine

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Isolation of Caffeine Introduction Caffeine is a stimulant found in the cacao plant that is used, today to increase alertness when taken in moderate doses. In this lab, we extracted caffeine from 2 NoDoz tablets, which contains 45% caffeine. We accomplished this task by performing a hot gravity filtration to separate the insoluble binder from the caffeine, a liquid extraction to separate the organic caffeine-containing layer from the aqueous layer, a gravity filtration to filter off the hydrated salts, a steam bath evaporation to evaporate out the organic solvent, and a recrystallization to obtain dry caffeine crystals. The ultimate goal of this lab was to acquire the same amount of caffeine as listed on the NoDoz tablets. Materials and Methods Materials The compounds used in this lab are listed in the table below: Procedure We boiled 2 NoDoz tablets in grinded form with 60 mL of water in a 100 mL beaker and allowed it to cool to room temperature after it had been sitting on the hot plate for 5-10 minutes. Next, we performed a hot gravity filtration by pouring the hot aqueous solution of water and NoDoz (caffeine and insoluble binder) through a large Buchner funnel into an Erlenmeyer flask. We discarded the collected insoluble binder collected inside of the Buchner funnel and performed an extraction by mixing the aqueous solution collected in the Erlenmeyer flask (aqueous solution of water and caffeine) and 15 mL of methylene chloride in a separatory funnel and swirled until the layers had separated to form an aqueous layer on top and an organic layer containing the solvent and caffeine at the bottom of the funnel. We drained the lower layer into an Erlenmeyer flask and repeated the extraction. Next, we added anhydrous sodium sulfate to the Erlenmeyer flask, which contained the combined organic layers of the 2 extractions,
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