Metabolism Essay

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Metabolism GRT1 Task 208.5.4-01, 03-05, etc. A1. Role of enzymes in process Enzymes are proteins that will bind to a substrate to help carry out a specific chemical reaction, and the end result of this is a new product. The substrate binds to the active site of the enzyme. This is called the ES complex. The enzyme will remain the same throughout the process and will continue to do the same job over and over again to form the next product. A catalyst is an enzyme that works to either help increase or decrease the speed of a chemical reaction. Enzymes also lower the activation energy whenever they are present, and they do so without being used or changed within the reaction. A2. Deficiency in Aldolase B Aldolase B is used to help breakdown fructose. It will form the products DHAP and glyceraldehyde, which enter the glycolysis cycle and produce ATP. If the body is unable to produce aldolase B, there will be a build up of fructose-1-phosphate in the body. The levels of fructose-1-phosphate will become toxic in the body, which will create many problems. This is called Hereditary fructose intolerance. The problems that many can face with this include, low energy, hypoglycemia, and eventually cellular death. A3a. Diagrams of Lock and Key Model A3b. Diagram of Activation Energy A4. Substrate The substrate of Aldolase B is fructose-1-phosphate. This comes from the breakdown of fructose by the use of fructokinase. Aldolase B is then converted into 2 products, DHAP and glyceraldehyde. These products can easily enter the glycolysis cycle to make ATP for our bodies. ATP is energy. A5. Role of Aldolase B The role of aldolase B is to help with the breakdown of fructose. Aldolase B is product of the substrate fructose -1-phosphate. When aldolase B is broken down, it creates the products DHAP and glyceraldehyde. The products can then enter the

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