Beta Sheet Refinement in Bhageerath

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BETA SHEET REFINEMENT IN BHAGEERATH MAJOR PRJECT REPORT Department of Chemistry Indian Institute of Technology, India Hauz Khas, New Delhi -100016 Submitted by: MAREEDU NARASIMHARAO 2011CYS7166 Under the supervision of:Prof. B JAYARAM 1 CERTIFICATE This is to certify that the project report entitled “BETA SHEET REFINEMENT IN BHAGEERATH” being submitted by Mr MAREEDU NARASIMHARAO to Indian Institute of Technology, Delhi for Minor Project, is a record of bonafide research work carried out by him. Mr MAREEDU NARASIMHARAO has worked under my supervision and guidance and fulfilled all the requirements for the submission of Major project report, which to my knowledge has reached the requisite standard. (Prof. B Jayaram) Supervisor Department of Chemistry Indian Institute of Technology, Delhi Hauz Khas, New Delhi- 110016, India 2 ACKNOWLEDGEMENT I would like to thank my supervisor Prof. B Jayaram for accepting me as his student and giving me the opportunity to work under his guidance. He had been tremendously helpful throughout the project and has always made himself available for me in spite of his very busy schedule. I am grateful to Dr. Shashank Shekar for her valuable suggestions,. I would like to express heartiest gratitude to Avinash Mishra and all other lab members who were of great help during my work. I would express my gratitude to our Head of the Department Prof. A.Ramanan and also to our M.Sc. Coordinator Dr. Nidhi Jain. I would also like to thank my parents and my friends who have supported me throughout. 3 1. Introduction. Most of the essential structures and functions of the cells are realized by proteins, which are chains of amino acids with stable three-dimensional structures. A fundamental principle in all of the protein science is that protein functions are determined by their structures. However, it is extremely
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