Lymphocyte Signaling System

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AnatomyII The Lymphocyte Signaling System The human immune system has an amazing and effective defense mechanism. Within our circulatory system is an army of white blood cells ready and waiting to attack any foreign invaders. This system of attack is extremely specialized, being composed of a team of cells, which can be found in various areas of the body including the blood, thymus, lymph nodes, spleen, and the appendix. For a fully functioning immune system to do its job, two main things need to happen. Initially, the body has to recognize that it is under attack from foreign microorganisms. Once the alarm has been sounded, the immune response system has to quickly respond before the invaders have a chance to harm the body. These special attack forces are known as lymphocytes and have adapted to working in teams to accomplish their job. As with any team, there is a specific order in which events have to happen to effectively control any bacterial or viral infection that may attack the body. The first line of defense is known as the T Helper cells. They have an integral role in both cell mediated and antibody immune responses. These cells are present in numerous amounts throughout the blood, lymphatic system, and lymph nodes. When a body’s macrophages take in a foreign invader, it displays the antigens on the membrane’s surface. This display is what sends out the distress signal that initiates the attack. The T Helper will bind to the antigen on the macrophage releasing cytokines, which have several roles including growth and division of T cells, initiating immune response and stimulating division of cytotoxic T cells. Without this signal to attack, the body would be almost completely defenseless. This distress signal initiates the next wave of attack. The second wave of response is led by the B cells, which are the primary players in the antibody

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