Dnas Primary and Secondary Structure in Relation to Its Physical Properties.

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The nucleic acid, DNA has an individual structure that act as an information storage molecule that provides instuction for assembling proteins. DNA’s primary structure involves nucleotide sequences that are monomer repeats which form polynucleotide chains[1]. The Primary structure of DNA begins with one of the two different 5 -carbon sugar components either known as 2-deoxyribose. The particular sugar can then either be linked to a hetrocyclic base by an N – Glycosidic bond[2]. The hetrocyclic bases are derived from two different structures which inculde Purine and Pyrimidine. The Purine chemical structure involves a six and a five membered ring, where the Pyrimdine structure includes single six membered rings[2]. Each nucleotide sequence has one of the following bases which involve double membered rings always pairing with single membered rings through hydrogen bonding [1]. There are three major Pyrimidines; these include Cystosine, Uracil (base involved in RNA) and Thymine. The two major Purine bases include Adenine and Guanine which bind to its complementary base pair Thymine and Cystosine respectively[1]. Chemical modification of DNA takes place due to alkylating agent Methl Iodine binding to certain bases within the DNA. This Methl Iodine binding has a large potential to cause genotoxic potency within DNA, causing methylated Guanines and becoming susceptible to DNA damage[1]. The bonding between base pairs, particularly Guanine and Cystosine content joined through complemetary hydrogen bonding have great significance with the melting temperature of DNA. Due to Guanine and Cystosine content having three complementary bonding sites, in comparision to Adenosine and Thyosine only having two hydrogen binding sites, allows Guanine and Cytosine content to have a stronger bond between bases and allow for a higher melting temperature [1]. The final component

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