Annotated Bibliography On Skin Cancer

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Name:_____________________________ Per. _____ Annotated Bibliography (1) Three relevant articles from professional scientific journals (these have abstracts and references in them) (2) Two relevant articles that do not need to be from professional journals (but they can be if you’d like) For each article: (a) 1/2-page summary; (b) bibliographic reference; (a and b should be on a separate page in front of the article it is referring to) (c) photocopy of entire article for each of following sources; (d) highlight relevant points: | |Prof Art #1 |Prof Art #2 |Prof Art #3 |“Other” Art #1 |“Other” Art #2 | |1/2-page | |…show more content…
Ref. | | | | | | |Article Copy | | | | | | |Highlighted | | | | |…show more content…
NMSC is the most common cancer in humans. UVB rays are absorbed into the skin, producing, burns, and eventually skin cancer. Recent surveys indicate that about 1 million new cases o f skin cancer are diagnosed every year in the US. 70% of which have resulted from overexposure to sunlight. Studies show that UVB rays are responsible for this effect. The first step in UV skin carcinogenesis (creation of cancer) involves DNA damage. Occasional mistakes of DNA repairs lead to the integration of incorrect bases into the genetic material. The DNA that is left unrepaired may disrupt cellular processes by disrupting the DNA and RNA synthesizing machineries with incorrect genetic sequenses. These mistakes result in mutation leading to loss or inappropriate expression of affected genes. Studies indicate that genetic alterations in the P53 tumor suppressor gene play an important role in the development of skin cancer. The p53 gene is also involved in apoptosis (programmed cell death), and it has been proposed that p53 serves as a “guardian of the genome” by aiding in DNA repair or by going through apoptosis to elimated cells with excessive DNA damage. Unrepaired damage in the p53 gene are transformed into mutations thereby initiating the process of carcinogenesis. Following repeated exposures to UV, keratinocytes (sunburn cells) carrying

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