Neurofibromatosis Essay

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Neuro Fiber Mitosis A genetic disorder is a disease that is caused by a different form of a gene called a variation, or a mutation. Many diseases have a genetic aspect. Some, including many cancers, which are caused by a mutation in a gene or group of genes in a person's cells. These mutations can occur randomly or because of an environmental exposure such as cigarette smoke. Genetic Disorders like von Recklinghausen disease or more commonly known, as neuro fiber mitosis are a group of three genetically disorders that cause tumors to grow in the nervous system. The tumors begin in the supporting cells that make up the nerve and the myelin sheath that is the thin membrane that protects the nerves, rather than the cells that actually transmit information. The type of tumor that develops depends on the type of supporting cells involved. Scientists have classified the disorders as neurofibromatosis type 1 (NF1) and type 2 (NF2), and a type that was once considered to be a variation of NF2 but is now called schwannomatosis. An estimated 100,000 Americans have a neurofibromatosis disorder, which occurs in both sexes and in all races. Neurofibromatosis is an autosomal disorder, which means that only one copy of the affected gene is needed for the disorder to develop. Which means if only one parent has neurofibromatosis, his or her children would have a fifty percent chance of developing the condition as well. The severity in affected individuals can vary; this may be due to variable expressed. About half of the cases are due to de novo mutations and no other affected family members are seen. Why these tumors occur still isn’t completely known, but it seems to be related mainly to the mutations in genes that play key roles in suppressing cell growth in the nervous system. These mutations keep the genes from making normal proteins that control the cell production.

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