2 marks 4 Draw the structural formula of Compound G. 1 mark 5 Using the chemical shift correlation for 13C NMR, predict the number of peaks for Compound G and draw in the position of the peaks on the blank spectrum below, annotating each peak with its corresponding structure. (2 marks) 6 Draw the structural formula for 2-chloro but-2-ene. Below this draw a structural formula of an isomer of 2-chloro but-2-ene and name this substance.
Substitutive Nomenclature: treats the halogen as a halo substituent on an alkane chain. The carbon chain is numbered in the direction that gives the substituted carbon the lower number. 4.3 IUPAC Nomenclature of Alcohols Place the Ol at the end 4.4 Classes of Alcohols and Alkyl
Histidine; imidazole group side chain; polar positively charged 3. Alanine; methyl group side chain; non-polar 4. Arginine; guanidinium group side chain; polar positively charged 5. Cysteine; thiol group side chain; polar neutral 6. Proline; pyrrolidine side chain; non-polar 7.
The reaction is a synthesis. The Kc for this reaction is Kc = 49.7 at 458oC [Answer: [H2] = [I2] = 1.2 × 10-2 M, [HI] = 8.6 × 10-2 M] 2. Iodine and bromine react to give iodine monobromide, IBr. What is the equilibrium composition of a mixture at 150oC that initially contained 0.0015 mol each of iodine and bromine in a 5.0 L vessel? The equilibrium constant Kc for this reaction at 150oC is 1.2 102.
Halides Structure BP 1-Chlorobutane 77-78°C 1-Bromobutane 100-104°C 2-Chlorobutane 68-70°C 2-Chloro-2-methylpropane 51-52°C Bromobenzene 156°C 1-Chloro-2-butene (trans) 68°C 1-Chloro-2-butene (cis) 63.5°C 1-Chloro-2-methylpropane 68-69°C 2-Bromobutane 91°C 2-Bromo-2-methylpropane 71-73°C Procedure: 1. Label 11 small containers and place 0.1 mL of each of the following halides in the tubes 2. Arrange the labeled tubes into the following groupings a. 1-Chlorobutane b. 1-Bromobutane c. 1-Chlorobutane d. 2-Chloro-2-methylpropane e. Bromobenzene f. 1-Chloro-2-butene mixture of cis and trans isomers g. 1-Chloro-2-methylpropane h. 2-Bromobutane i.
5 12WAB10835 Dioxane; 7 123-91-1 GC/FID; CSC 5 12WAB09523 Diphenylamine; 22; Fully Validated 122-39-4 HPLC/UV; Bubbler with Isopropyl Alcohol 5 12WAB10906 Diphenylamine; 78; Fully Validated 122-39-4 HPLC/UV; GFF coated with Sulfuric Acid 5 12WAB10073 Diphenyl; PV2022; Partially Validated 92-52-4 GC/FID; XAD-7 5 12WAB10850 Dipropyl Disulfide; PV2086; Partially Validated 629-19-6 GC/FID; Chromosorb 106 5 12WAB10450 Dipropylene Glycol Methyl Ether; 101; Fully Validated 34590-94-8 GC/FID; CSC 5 12WAB10905 Disulfoton; PV2105; Partially Validated 298-04-4 GC/FPD; OVS-2 5 12WAB11596 Diuron; PV2097; Partially Validated 330-54-1 HPLC/UV; OVS-2 5 12WAR11371 Divinylbenzene; 89; Fully Validated 108-57-6 GC/FID; CSC coated with TBC 5 12WAB10451 Dursban; 62; Fully Validated 2921-88-2 GC/FPD; OVS-2 5 12WAB10449 Endosulfan; PV2023; Partially Validated 115-29-7 GC/ECD; OVS-2 5 12WABI0801 Enflurane; 29; Fully Validated 13838-16-9 GC/FID; CSC 5 12WAB10448 Enflurane; 103; Fully Validated 13838-16-9 GC/FID; Anasorb CMS or Anasorb 747 5 12WAB09860 Epichlorohydrin; 7 106-89-8 GC/FID; CSC 5 12WAB09198 Estradiol; PV2001; Partially Validated 50-28-2 HPLC/UV; GFF 5 12WAB10447 Estriol; PV2001; Partially Validated 50-27-1 HPLC/UV;
6) Which amino acid has more restrictive bond rotation and why? Proline is the most restrictive because its side chain has a lot of hindrance. This limits the bond rotation. 7) Which amino acid has less restrictive bond rotation and why? Glycine has the less restrictive bond rotation because it has the smallest side chain.
2-propanol (bp=82 degrees C) 3. tetrahydofuran (bp=65 degrees C) 4. 1-butanol (bp=118 degrees C) 5. butanone (bp=80 degrees C) Give a better separation for the mixture to be distilled tetrahydofuran (bp=65 degrees C) because it is farthest from 100 degrees C Which alkyl halide would react fastest in a nucleophilic substitution using silver nitrate in ethanol (weak nucleophile, protic solvent)? 3-bromo-3-methylpentane (most
Carboxylic acid to ketone, formation of acetal Which involves nitrile? R-MgX, H3O+, formation of cyanohydrin Which involve lithium? * Dithiane to Ketone (BuLi) * Carboxylic Acid to Ketone (Li-R) * Gilman/Acid Chloride to Ketone (R2CuLi) * Acid Chloride to Aldehyde (LiAlH(O-t-Bu)3 * Reduction of aldehydes, ketones, carboxylic acids (LAH) * Reduction of alcohol (TsCl, LAH) Aldehydes are more reactive than ketones Aldehydes and ketones have high bp but lower than alcohol Nomenclature: * Aldehyde: -al, as substituent: -formyl * Ketone: -one, as substituent: - oxo 0.9, 1.3, 1.4, 2.1, 2.5, * CH3, CH2, CH, COCH3, C---CH 3-4, 5-6, 1.7, 7.2, 2.3, * CH2X, C=CH2, C=CCH3, Ph-H, Ph-CH3 9-10, 10-12, 2-5, 4-7, 1.5 – 4 * Aldehyde, Carboxylic acid, R-OH, Ar-OH, R-NH2 O-H = 3300 N-H = 3300 C=O = 1700 C=C = 1660 IR Trends: * Ketones carbonyl frequencies are lower than aldehydes because conjugation * Conjugation lowers frequencies * Ring strain increases it HNMR trends: Ketone protons are lower than Aldehyde protons MS: * M+ peak is total * 15 = methyl * 29 = ethyl * 43 =
Experiment Title: Acid-Base Extraction: Separation of an Organic Acid, a Base and a Neutral Compound 1) -Mass of benzoic acid isolated = 0.893 g -Percent recovery of benzoic acid = 89.3% -Melting point of benzoic acid = 121 °C – 122 °C -Mass of 4-chloroaniline isolated = 1.2 g -Percent recovery of 4-chloroaniline = 120% -Melting point of 4-chloroaniline = 53°C – 60 °C -Mass of naphthalene isolated = 1.36 g -Percent recovery of naphthalene = 136% -Melting point of naphthalene = 65 °C – 70 °C 2) The differences in the masses of the compounds before and after the experiment may include the possibility that the solids were not dried completely since the masses afterward were larger than 1 g for both 4-chloroaniline and naphthalene. The wet solids may have added more weight. One reason to explain a mass less than 1 g fro Benzoic acid may deal with the possibility that not all of the components of the solid was collected properly. There may have also been a problem with the way that the solids were weighed on the scale and this could account for the differences. 3) The reason for the fact that the solvent used in an extraction should have a low boiling point is so that the solvent itself can evaporate out of the mixture.