Teratoma Case Study

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Abstrcat: We report a rare case of mature teratoma malignant transformation in right adrenal in a 36-year-old Chinese female. The patient had no any symptoms until the physical examination was found. Abdominal non-enhanced spiral CT scan showed a huge tumor with a mixing density in right adrenal region. The tumor had cystic, fat, as well as calcification. The most significant was that enhanced CT showed strengthed nodules of attaching to the wall. In addition, the patient had three abnormal laboratory results, including cortisol 773.58 mol/L (reference range 118.6 to 618 mol/L), adrenocorticotropic hormone (ACTH) 70.980 pg/ml (reference range 7.2 to 63.3 pg/ml), aldosterone 317.84 (reference range Clinostatism: 49.3-175pg/ml; Stand: 34.7-275pg/ml;…show more content…
It can be divided into three types: (1) mature cystic and solid teratoma, its biological characteristic is benign. (2) not maturity teratoma, differentiated into immature, slightly mature and fully mature, its biological characteristic can be benign, malignant or neutral. (3) mature teratoma malignant transformation, most occur in the areas of cystic. Malignant teratoma included three histological forms: immature teratoma; teratoma with other malignant germ cell tumor components; and teratoma with malignant transformation[1]. Muture adrenal teratoma malignant transformation is more rare, case reports as…show more content…
It occurs in 1-2% of mature ovarian cystic teratomas and 2-3% of testicular teratomas. TMT of extra gonadal origins is even rare and has been described only in the mediastinum, stomach, brain and sacrococcygeal region[2] . But adrenal TMT is quite rare, so far, in “adrenal teratoma malignant transformation” for keywords, retrieve the pubmed of literatures in recent 20 years, we can search some references[2-4,7-19], only two articles can be found about adrenal TMT[2,3]. Adrenal teratoma occupies about 0.13% of the adrenal tumor[5]. In the clinical, adrenal teratoma is most occured in young women, the right area and 90% are benign[6]. The patients have no symptoms in the early time. Most of them can be found in the hospital routine physical examination. With the increase of the tumor, the oppression of the surrounding organs or secondary infection can cause the symptom, such as low back pain, paroxysmal abdominal pain [7]. In our case , the patient was diagnosed as hamartoma by radiologist at first. This may be that hamartoma and teratoma have similar compositions including fat, smooth muscle, fibrous tissue, blood vessels and calcification, but the cystic change of the hamartoma are relatively rare. The characteristics of our case is that enhanced CT present the strengthed nodules of attaching to the wall which can be seen in the malignant ovarian disease. So we can infer that

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