Diseases: Multiple Sclerosis

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From Wikipedia, the free encyclopedia Multiple sclerosis Classification and external resources Demyelination by MS. The CD68 colored tissue shows several macrophages in the area of the lesion. Original scale 1:100 ICD-10 G35 ICD-9 340 OMIM 126200 DiseasesDB 8412 MedlinePlus 000737 eMedicine neuro/228 oph/179 emerg/321 pmr/82 radio/461 MeSH D009103 GeneReviews Multiple Sclerosis Overview Multiple sclerosis (MS), also known as "disseminated sclerosis" or "encephalomyelitis disseminata", is an inflammatory disease in which the fatty myelin sheaths around the axons of the brain and spinal cord are damaged, leading to demyelination and scarring as well as a broad spectrum of signs and symptoms.[1] Disease onset usually occurs in young adults, and it is more common in women.[1] It has a prevalence that ranges between 2 and 150 per 100,000.[2] MS was first described in 1868 by Jean-Martin Charcot.[3] MS affects the ability of nerve cells in the brain and spinal cord to communicate with each other effectively. Nerve cells communicate by sending electrical signals called action potentials down long fibers called axons, which are contained within an insulating substance called myelin. In MS, the body's own immune system attacks and damages the myelin. When myelin is lost, the axons can no longer effectively…show more content…
Possible targets of the immune response include myelin basic protein (MBP) and proteolipid protein (PLP). The commonly prescribed MS drug Copaxone was designed to mimic MBP and therefore act as a decoy for autoreactive immune cells. Even so, the role of MBP in MS is controversial; it is buried within the myelin sheath (rather than on the surface), where immune cells would not be able to recognize

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