The Effects of Penicilin.

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ANTIBIOTICS 1. For each of the following antibiotics name the microorganism responsible for their production, using the appropriate naming convention. a) Penicillin: Penicillium chrysogenum/P.notatum b) Erythromycin: Saccharopolyspora erythraea c) Vancomycin : Amycolaptosis orientali 2. Explain why antibiotics are produced by microorganisms. Antibiotics are produced by microorganism because they inhibit the growth of or kill other microorganisms; they are effective in low concentrations and act on specific species of microorganisms. 3. List four different ways that the antibiotics work to destroy or inhibit microorganisms and for each give named example of an antibiotic exhibiting this type of mechanism. (Note: you need to indicate the different processes or structures affected not simply variations or subsets of a process) Inhibit cell-wall formation: blocks a specific cross linking step in the bacteria in the process of reproduction. E.g. of antibiotic Penicillin G Damage the cell membrane: causes the cell to take up too much water and lyse by increasing the permeability of the cell membrane. E.g. of antibiotic is Polymyxin B Interfere with protein synthesis: prevents the productions of protein in the invading bacterial cells. E.g. of antibiotic is Vancomycin. Inhibit nucleic acid metabolism: blocks the recycling of the lipid carrier molecule needed to transport the peptidoglycans in the bacteria. E.g. of antibiotic Bacitracin (Reference for all the answers to question 3 = and ) 4. Some antibiotics are referred to as being broad spectrum and some as narrow spectrum. Give a named example of each type of antibiotic and explain what these terms mean. Broad spectrum: An antibiotic that is effective against a wide range of infectious microorganisms which includes both gram positive and gram negative bacteria is called as a

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