Homeostatic Imbalances: the Case of the Man with the Swollen Kidneys

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Homeostatic Imbalances: The Case of the Man with the Swollen Kidneys Clinical Presentation: 49 years of age White male Presents: Blood in the Urine Fever Sever Lumbar Pain Physical Exam: Bilateral Lumbar Tenderness Bilateral Renal Enlargement Liver Enlargement Ankle and Facial Edema Skin pallor Lung sounds suggest pulmonary edema Vital Signs: Blood Pressure: 172/100 Heart Rate: 92/min Body Temperature: 102.2F (39c) Tests and Indications: Blood: Red Blood Cells: Decrease indicates anemia. White Blood Cells: Increase suggests infection. Chemistry: Potassium: Increase suggests reduced renal secretion of Potassium. Calcium: Decreased due to reduced reabsorption. Phosphate: Increase due to reduced excretion in urine. Blood Urea Nitrogen: Increase indicates inability to excrete urea; suggest renal dysfunction. Creatinine: Increase indicates inability to excrete Creatinine; suggests renal dysfunction. Albumin: Decrease indicates loss of protein into urine. pH: Decrease indicates acidosis Urinalysis: Protein: Significant increase due to loss in urine: suggest renal dysfunction. Glomerular Filtration Rate: Significant decrease indicates reduced renal filtration; suggests renal failure. Bacteria: Presence suggests renal infection. Urinary Protein Concentration: Presence indicates renal dysfunction. Red Blood Analysis: Presence indicates renal dysfunction. Chemistry: * Genetic Screening indicates that Mr. Newman has a mutation on Chromosome 16. * The mutation results in the formation of an abnormal membrane protein called polycystin. Cellular Defects: * A genetic mutation has resulted in the formation of cysts in Mr. Newman’s kidneys. * Cysts form when cells in a region of the nephron divide rapidly. * Proximal Tubules cells have divided to form a dilated segment. * The dilated segment

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