Flagellum Case Study

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Flagellum is a crucial characteristic to the motility and colonization of Proteus mirabilis.it is also linked to the ability of this bacteria to form biofilms, assisting in the bacteria’s resistance to the host defenses and selecting antibiotics .It also acts as a surface sensor. P. mirabilis is a peritrichious flagellated bacterium .which gave it the ability for swarming motility.( Armbruster and Mobely.2012; Belas and Suvanasuthi.2005).(32,124) These flagella form a bundle that propels the cells forward on the surrounding fluid(Tuson et al.,2013)(128) Proteus mirabilis elevates its flagellar number, from fewer than (10 to up to 5,000), and its length from (1 to 2 m )to (20 to 80 m), over differentiation from the swimmer to the swarmer cell type (McCarter,2010)(126) Adhesins fimbriae 1.4.1.2- Fimbriae are appendages on the bacterial surface which is used for adherence (Morgenstein.2011) (129), consisting of a polymer of a single polypeptide subunit interspersed with adhesive proteins. The fimbriae are arranged around the bacterial cell in a peritrichous form (Rocha et al.,2007)(130). The adhesion of Bacteria to the uroepithelium is an essential step for the colonization and infection, especially in a system of continuous urinary flow.(Pearson et al.,2008)(7). It's consider one of the…show more content…
The genetic organization of the PMF fimbriae operon revealed five functional genes pmf .these gene cluster encoded by 5655 bp that predicted five polypeptides: PmfA (18.9 kDa) major fimbrial subunit, PmfC (93.1 kDa), the usher, PmfD (28.2 kDa), the chaperone , PmfE (38.9 kDa), the minor subunit and PmfF (19.6 kDa),the adhesion one (Zuino et al.,2003; Rocha et al.,2007)(130). Zuino and his co-workers determined the role of PMF in the virulence of P. mirabilis. This study suggests an important role of this fimbria in P. mirabilis colonization of bladder and kidneys (28,29).( Zunino et al.,2003; Massad and

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