Endocrine System and Age Related Changes

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Factors that Affect Endocrine Function Everyone's body undergoes changes, some natural and some not, that can affect the way the endocrine system works. Some of the factors that affect endocrine organs include aging, certain diseases and conditions, stress, the environment, and genetics. Aging Despite age-related changes, the endocrine system functions well in most older people. However, some changes occur because of damage to cells during the aging process and genetically programmed cellular changes. These changes may alter the following: ›hormone production and secretion ›hormone metabolism (how quickly hormones are broken down and leave the body) ›hormone levels circulating in blood ›target cell or target tissue response to hormones ›rhythms in the body, such as the menstrual cycle For example, increasing age is thought to be related to the development of type 2 diabetes, especially in people who might be at risk for this disorder. The aging process affects nearly every gland. With increasing age, the pituitary gland can become smaller and may not work as well. For example, production of growth hormone might decrease. Decreased growth hormone levels in older people might lead to problems such as decreased lean muscle, decreased heart function, and osteoporosis. Aging affects a woman's ovaries and results in menopause, usually between 50 and 55 years of age. In menopause, the ovaries stop making estrogen and progesterone and no longer have a store of eggs. When this happens, menstrual periods stop. Diseases and Conditions Chronic diseases and other conditions may affect endocrine system function in several ways. After hormones produce their effects at their target organs, they are broken down (metabolized) into inactive molecules. The liver and kidneys are the main organs that break down hormones. The ability of the body to break down hormones may

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