Photoacoustic Imaging Essay

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Photoacoustic Tomography Introduction The use of the photoacoustic effect in an imaging modality may provide solutions to imaging problems that could influence aspects of research and future clinical protocol. Photoacoustic tomography (PAT) is based on the photoacoustic effect: the detection of sound waves generated by the non-ionizing irradiation of tissues with electromagnetic pulses. The first reported observations of sound waves being generated by light were by Alexander Graham Bell in 1880(1). Images created by PAT obtain high contrast and high spatial resolution due to the combination contrast due to light absorption with ultrasonic resolution. Certain biological tissues preferentially absorb distinct wavelength values of electromagnetic (EM) radiation than others. This is what drives the formation of contrast in PAT. When an EM pulse is used to irradiate the tissues, absorption of the EM energy generates heat and the subsequent expansion of the absorbing tissue. This expansion causes the emission of acoustic waves (2). The acoustic waves generated from the absorbing tissue reach the detectors in the transducer array at different times. This time delay leads to the precise localization of the source tissue and creation of a map of the function of electromagnetic energy deposition. To obtain a PAT image, many photoacoustic images are taken at different angles by pulsing electromagnetic radiation onto a tissue which is suspend in a bath while a piezoelectric transducer detects the generated photoacoustic waves to reconstruct an image. PAT suffers from optical scattering, which lowers the spatial resolution with an increasing depth in soft tissues (3). PAT has a variety of applications in the many emerging fields of scientific research and may one day prove to be a valuable resource in a clinical setting. It is a unique form of imaging in that it can

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