Trazodone Research Paper

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| | |Role of Trazodone and Mirtazapine (Ramelteon) for insomnia in elderly people | | | Insomnia is common condition and serious problem in elderly population.1 It is characterized by difficulty in initiating, maintaining sleep.1,2 According to the National Sleep Foundation Sleep in American survey in 2005, approximately 54% of American adults had experienced more than one symptom…show more content…
According to National Institute of Health concluded that, Pharmacological treatment may be useful for acute and transitional insomnia. Despite of many positive outcomes of randomized clinical trials of hypnotics drugs have several long term side effects, such as impairment in memory and psychomotor, dependency and tolerance issue. 5The overall rate of prescribed medication for insomnia fell by 24 % between 1987 and 1996.3 Moreover, FDA approved hypnotics use declined by 54% in the treatment of Insomnia, while the use of trazodone and other antidepressants medications rose by 146%. 3 This trend continued through 2002, such that trazodone became the most frequently used medication for the treatment of insomnia and there are other antidepressants, antipsychotic and sedatives gain favor for the treatment of insomnia.4 The preferential use of off label medication for insomnia suggests that there must be substantial evidence supporting this practice. One of the studies was performed in Somerset West, to measure the effect of trazodone 100 mg, as compared to placebo on objective and subjective sleep and awakening quality in depressed patients.6 In this single blind, placebo controlled cross over study one group of eleven patients aged 35-75 years with the diagnosis of nonorganic insomnia related to major depressive episode were included and compared with the same age of control group.6 Patients were also essential to meet DSM-IV criteria for diagnosis of nonorganic insomnia related to major depressive disorder.6 Patient with history of substance or alcohol abuse and trazodone hypersensitivity, significant medical disorders, pregnant and lactating women were excluded from this study.6 During the study patients were not allow to use of sedatives, antidepressants, narcotics or anticholinergic.6 Patients were inspected adaptation night, followed by placebo/baseline night and Trazodone, 100

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