Fen-Phen Research Paper

2061 Words9 Pages
In a nation obsessed with weight loss nothing has ever been anything quite like Fen-Phen. “It was set of magic pills from the wizards of Big Pharma” (Frankel, 2005). The drug was a prescription “cocktail” that promised to suppress appetite and promote weight loss easily and safely. Fen-Phen was an anti-obesity medication (an anorectic) which consisted of two drugs: fenfluramine and phentermine. Fenfluramine came to the U.S. market in 1973 as a drug made to increase the levels of serotonin depressing the nervous system and helping to moderate mood and appetite. Phentermine was introduced in 1959 as an appetite suppressant for those facing an increased medical risk as a result of their weight. This drug has been linked to a number of side…show more content…
Unfortunately, Fen-Phen also ended up stimulating the serotonin 2B receptor, which eventually led to the problems with the heart (Madrigal, 2008). In September 1997 the Food and Drug Administration (FDA) announced a voluntary withdraw of Fen-Phen by the drug company. This action was based on new findings from doctors who had evaluated patients taking these two drugs with echocardiograms, a special procedure that can test the functioning of heart valves. These findings indicate that approximately thirty percent of patients who were evaluated had abnormal echocardiograms, even though they had no symptoms. This was a much higher than expected percentage of abnormal test results. These new findings suggested that fenfluramine and dexfenfluramine are the likely cause of heart valve problems of the type that prompted FDA’s two earlier warnings concerning “Fen-Phen,” a combination of fenfluramine and phentermine (Bachorik, 1997). American Home Products was accused of withholding information that would have warned Fen-Phen users of the risks involved so they could continue to sell the popular diet drug (Fen-Phen Lawsuit). One of the main side effects of Fen-Phen is primary pulmonary hypertension. This is a fatal disorder, resulting in the death of sufferers when blood vessels in the lungs constrict and cause a thickening and shutting down of the lung’s blood vessels. This creates…show more content…
In the retrial, the prosecution was allowed to show that the defendants, in surrendering their licenses last year, admitted they had violated ethics rules by failing to tell their clients the total amount of the settlement, the number of other clients, and the fact that they were taking more than 49 percent of the settlement as fees, well above the amounts set in their contract (Wolfson, 2009). Shirley Cunningham Jr. and William Gallion were convicted on April 3, 2009 after a jury found the disbarred lawyers guilty of conspiracy and wire fraud charges in relation to a $200 million 2001 Fen-Phen settlement that should have gone to 440 former clients they represented in the 2001 Boone Circuit Court case. The jury's guilty verdict came after two days of deliberations and after hearing more than five weeks of testimony in the trial (Musgrave, 2009). A federal jury ruled on April 7, 2009 that Cunningham and Gallion must forfeit $30 million, and they must also turn over an unspecified amount held in separate accounts, this could be as much as $20 million more. The separate accounts the jury referenced had comprised the Kentucky Fund for Healthy Living Charity account, which the former lawyers set up using money collected in the scheme (Biesk, 2009). Cunningham and Gallion face sentencing on July 27, 2009 (International, 2009). The case has also gained national attention because Gallion and Cunningham allegedly also used some of the money
Open Document