Discuss the Role of Endogenous Pacemakers in the Control of Biological Rhythms

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Biological rhythms are a pattern of physiological processes that are accompanied by psychological changes that repeat on a regular basis. There are three main biological rhythms: circadian, infradian and ultradian. Circadian rhythms have a 24 hour cycle; an example of a circadian rhythm would be sleep as it is repeated once every 24 hours. The menstrual cycle is an example of an infradian rhythm as the cycle is longer than a day (once a month, once a year, etc.) Finally an ultradian rhythm has a cycle shorter than 24 hours, it changes within a 24 hour period, and an example of this would be heart rate. Endogenous pacemakers are the inherited mechanisms that work internally monitoring the exogenous zeitgebers that help to synchronise biological rhythms to external cues such as night and day. An example of an endogenous pacemaker is the supra-chiasmatic nucleus, which is a section of the brain above the optic chiasm that controls circadian rhythms by regulating body rhythms in line with environmental light levels. Research conducted on hamsters shows that removal of the supra-chiasmatic nucleus results in randomised sleep walking patterns, this demonstrates that endogenous pacemakers have a key role in controlling biological rhythms as the removal of one would begin to randomise and alter biological rhythms. Another example of an endogenous pacemaker is the reticular activating system found within the brainstem, its role is to regulate arousal levels from sleep to focused attention and to also filter any external stimuli. Research conducted on cats by Moruzzi and Magoun found that by stimulating the reticular activating system while sleeping it awoke the cats, and by damaging the RAS it would induce a coma. This again, is an example of the role of endogenous pacemakers in controlling biological rhythms. Without endogenous pacemakers it is clear to see that it can

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