Compare and Contrast the Developments That Led to One Market Drug Launched in the Mid-20th Century and One Launched in the Past 25 Years.

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Compare and contrast the developments that led to one market drug launched in the mid-20th century and one launched in the past 25 years. Over a long period of time, the cost and the time taken for drug development has soared. The two examples that have been selected to compare and contrast are penicillin and sildenafil; where both have been arrived serendipitously. Penicillin discovery changed the course of medicine as the active ingredient that was discovered turned out to be an infection-fighting agent of enormous potency. The development of penicillin has served as the general model for most drug development and discovery during this specific time period. Research that resulted in sildenafil was originally conducted in order to find a lead compound with anti-hypertensive properties and over time a turning point had occurred, perhaps not the final one, where a completely new indication has been developed. In the early 20th century, a pandemic of diseases arose as a result of bacterial infections which killed many individuals due to the lack of available antibiotics. It was this series of incurable diseases that spurred research into drugs that could treat conditions caused by bacterial infection. In 1928, a Scottish biologist named Alexander Fleming made a serendipitous discovery of the antibiotic penicillin. On observation of the Staphylococci culture plates left for several weeks, he noticed contamination by fungi (Brown, 2005). Around the fungi moulds were zones of inhibition, suggestive of an agent or substance containing anti-bacterial properties being produced it. During further analysis, he realised that only the Penicillium mould produces this substance. The substance was then consequently named Penicillin and became available on the market in 1942 (Brown, 2005). [pic] Figure 1. Chemical structure of Penicillin (Fukami, T et al., 2006).

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