Clostridium Botulinum Essay

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Case Study The neurotoxin produced by the pathogen Clostridium botulinum is the cause of the 20-year-old man’s illness. The conclusion is based on the man’s symptoms and the ER doctor’s notation that the patient had consumed home-canned green beans. Food-borne botulism is a very rare neuroparalytic illness caused by the toxin produced by the C. botulinum bacteria (1). A very tiny amount of the toxin affects both the somatic and automatic systems and can cause death by respiratory failure (3). Clostridium botulinum is a Gram-positive, anaerobic rod-shaped organism often found in the soil and in sediments of lakes and oceans (4, 5). It prefers a low oxygen environment, and is capable of forming spores that can lay dormant until it finds a proper environment to grow (2). C. botulinum produces seven extremely potent neurotoxins (classified by letters A through G) – but according to the CDC only serotypes A, B, E and F are harmful to humans (2). These toxins enter the bloodstream and are capable of inhibiting the release of acetylcholine at the neuromuscular junction, preventing muscle contraction and lead to paralysis and eventually death (5, 7). There are four natural forms of botulism: food borne, infant, wound, and adult intestinal colonization (1). Food borne botulism (typically type A, B, or E toxins) is caused by ingesting food that has been in contact with contaminated soil and contains the spores. Improper canned goods and garlic/pepper infused oils with low acidity, high water activity, low concentration of salt, and no preservatives offer the organism a favorable anaerobic and nutritional environment to grow and produce the toxin (4). The spores are heat resistant and can survive improper prepared foods (5). Although, boiling canned goods for more than ten minutes will destroy the toxin (2, 5). A bulging can is due to gas production of the

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