Zyloprim Essay

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ZYLOPRIM (allopurinol) DESCRIPTION ZYLOPRIM is known chemically as 1, 5-dihydro-4H-pyrazolo 3, 4-d pyrimidin-4-one. It is a xanthine oxidase inhibitor which is administered orally. Each scored white tablet contains 100 mg allopurinol. Each scored peach tablet contains 300 mg allopurinol. CLINICAL PHARMACOLOGY Absorption: Zyloprim is approximately 90% absorbed in the gastrointestinal tract. Peak plasma levels generally occur at 1.5 hours and 4.5 hours for Zyloprim and oxipurinol. Excretion: Approximately 20% of the ingested Zyloprim is excreted in the feces. Because of its rapid oxidation to oxipurinol and a renal clearance rate approximately that of glomerular filtration rate, Zyloprim has a plasma half-life of about 1 to 2 hours. Zyloprim is cleared basically by glomerular filtration. Zyloprim decreases serum and urinary uric acid levels within 2 days. INDICATIONS Zyloprim is used to treat gout, leukemia, lymphoma, kidney stones, and also decreases uric acid levels in the urine in cancer patients. CONTRAINDICATIONS Patients who have developed a severe reaction or hypersensitivity to Zyloprim should not be restarted on the drug. Renal and hepatic impairments should be considered before using this drug. WARNINGS Patients should discontinue use if experience skin rashes or any other indication of an allergic reaction. This medication causes drowsiness and extreme caution should be used when driving, operating heavy machinery or participating in activities that calls for high alertness. Anyone with liver disease should get regular liver function tests when they begin taking Zyloprim. Doctor should also be aware of patients with kidney disease, diabetes, HBP, congestive heart failure, and if patient is receiving chemotherapy before prescribing this drug. PRECAUTIONS *Drug Interactions:

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