Wgu Grt1 Task 3 Essay

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BIOCHEMISTRY GRT1 Task 3 Breanna Jordan OXYGENATED/DEOXYGENATED HEMOGLOBIN • Oxygenated • Round • Oxygen binded • Rich in oxygen • Bright red • Travels from the heart via arteries to the rest of body • Oxygen measurement is the difference between oxygenated and deoxygenated hemoglobin • Deoxygenated • pyramid shape • Not binded to oxygen • Poor in oxygen • Darker red in color • Travels from the body back to the heart • Person with low level may have bluish color (Hudon-Miller, 2012) BOHR EFFECT • Oxygen binding capacity of Hb directly related to the ph of blood • Ph fluctuations dependent upon the amount of CO2 in blood • More CO2 , more acidic, lower ph, Hb lets go of more O2 • More oxygen, more alkaline, higher ph, Hb binds more O2 • Represented by the oxygen-dissociation curve • Vertical axis represents level of saturated Hb • Horizontal axis represents amount of oxygen available • Two curves: one with ph of 7.2 one with ph of 7.4 (Hudon-Miller, 2012) SICKLE CELL ANEMIA INHERITANCE • Recessive trait disorder • Inherited • Carrier has 1 normal gene and 1 sickle gene • Normal gene masks the dysfunctional gene • Must inherit gene from each parent to get the disease (Wolfe, 2000) (Hudon-Miller, 2012) Red Blood Cells -vs- Sickle Cells Red Blood Cells Sickle Cells • Round • Smooth • Pass easily through capillaries • 120 day life span • Sickle shaped • Stiff and sticky • Cannot pass through capillaries easily • Block cells that carry oxygen • 20-40 day life span SICKLE CELL ANEMIA • Glutamic acid replaced with valine at the 6th codon in betahemoglobin chain • Valine deoxygenates • RBCs polymerase • Forms long needle like fibers/chains • Becomes crescent shaped or sickle • Very viscous • Can not pass easily through vessels • Blood clots, strokes, severe pain, tissue damange (Hudon-Miller,

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