Synthesis of Aspirin

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Synthesis of Aspirin Abstract: Within this experiment, Acetylsalicylic acid, better known as Aspirin, is synthesized from the reaction of Acetic Anhydride, Salicylic acid, and Sulfuric acid (used a catalyst.) The procedure of the experiment itself employs vacuum filtration and recrystallization as methods of obtaining and purifying the product. The produced Aspirin is yielded as a relatively high amount in comparison to the theoretical yield. However, after employing Ferric Chloride testing and Melt-Temp comparisons, the purity of the product is seen to be rather low. The experimental procedure followed is ideal for production of an abundant, but relatively impure sample of Aspirin. This outcome would be favorable with the hopes of using the produced sample in further experiments, rather than for commercial use. Introduction: The purpose of this lab was not only an introduction to the techniques for organic synthesis, but to apply stoichiometric techniques to calculate theoretical yield. Throughout the lab, the main process and procedure that was followed was Organic Synthesis, which allowed for the synthesis of aspirin to the greatest yield possible. In this case, the molecule that was synthesized was Acetylsalicylic acid, better known as Aspirin. Aspirin is a molecule that many encounter on a daily basis as it is effective as a pain killer, fever reducer, anti-inflammatory, and antiplatelet. The synthesis of Aspirin is a result of a reaction between Acetic Anhydride and Salicylic Acid. The mechanism itself results in the transformation of Salicylic Acid’s hydroxyl group to an ester functional group. The reaction itself is a result of the introduction of an inorganic acid, that acts as a catalyst, which in this synthesis path was Sulfuric Acid. An important concept to be understood within this lab is the idea of a limiting reactant. What this implies
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