Research Polypharmacy Essay

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ORIGINAL RESEARCH ARTICLE Drugs Aging 2009; 26 (8): 687-701 1170-229X/09/0008-0687/$49.95/0 ª 2009 Adis Data Information BV. All rights reserved. Prescribing Optimization Method for Improving Prescribing in Elderly Patients Receiving Polypharmacy Results of Application to Case Histories by General Practitioners A. Clara Drenth-van Maanen,1 Rob J. van Marum,1 Wilma Knol,1 Carolien M.J. van der Linden2 and Paul A.F. Jansen1 1 Department of Geriatric Medicine, University Medical Centre, Utrecht, the Netherlands 2 Department of Geriatric Medicine, Catharina Hospital, Eindhoven, the Netherlands Abstract Background: Optimizing polypharmacy is often difficult, and critical appraisal of medication use often leads to one or more changes. We developed the Prescribing Optimization Method (POM) to assist physicians, especially general practitioners (GPs), in their attempts to optimize polypharmacy in elderly patients. The POM is based on six questions: (i) is undertreatment present and addition of medication indicated; (ii) does the patient adhere to his/her medication schedule; (iii) which drug(s) can be withdrawn or which drugs(s) is/are inappropriate for the patient; (iv) which adverse effects are present; (v) which clinically relevant interactions are to be expected; and (vi) should the dose, dose frequency and/or form of the drug be adjusted? Objective: The aim of this study was to evaluate the usefulness of the POM as a tool for improving appropriate prescribing of complex polypharmacy in the elderly. Methods: Forty-five GPs were asked to optimize the medication of two case histories, randomly chosen from ten histories of geriatric patients admitted to a hospital geriatric outpatient clinic with a mean – SD of 7.9 – 1.2 problems treated with 8.7 – 3.1 drugs. The first case was optimized without knowledge of the POM. After a 2-hour lecture on the POM, the
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