Premarin Research Paper

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Bioidentical hormones were first used for menopausal symptom relief in the 1930s,[1] after Canadian researcher James Collip developed a method to extract an orally-active estrogen from the urine of pregnant women and marketed it as the active agent in a product called Emmenin.[2] It was supplanted on the market when its manufacturer, Ayerst (later Wyeth Pharmaceuticals), began producing the more easily-manufactured conjugated equine estrogens in 1941 under the brand name Premarin; by 1992, Premarin was the most widely-prescribed drug in the United States.[3] In the 1970s, research and reports indicating risks from synthetic conjugated estrogens began to appear. Investigation determined that the addition of a progestogen to estrogen treatment…show more content…
Lee and Jonathan Wright were pioneers in the area of BHRT.[6] Lee authored several popular books on BHRT[7] and promoted custom-compounded BHRT, with the goal of achieving what he called a "natural hormone balance". He based this goal on the clinical testing of saliva to establish where "deficiencies" existed, though agencies such as the FDA and the American Congress of Obstetricians and Gynecologists state that blood and saliva testing is unreliable and biologically meaningless.[1] Lee also believed that progesterone acted as a panacea[8] and general health tonic for many health conditions; he based his claims on anecdotal data rather than peer-reviewed research,[7] and there have been no clinical trials demonstrating this to be true.[8] Wright also authored a popular book on BHRT;[6] he promoted a triple-estrogen formula he called "Triest", which combined the three estrogens (of over 25 types) found in human females: estriol, estradiol and estrone. Previous bioidential formulas
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