Phenylketonuria Outline

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Phenylketonuria (PKU) General Purpose: To inform Specific Purpose: To let the audience know that Phenylketonuria (commonly known as PKU) is an inherited disorder that increases the levels of a substance called phenylalanine in the blood. Central Idea: If PKU is not treated, phenylalanine can build up to harmful levels in the body, causing intellectual disability and other serious health problems. If the diet is not managed, (the child doesn’t get enough phenylalanine), he or she will not grow. INTRODUCTION I. Attention Material A. Phenylketonuria (PKU) is an inherited disorder that increases the levels of a substance called phenylalanine in the blood. Phenylalanine is a building block of proteins (an amino acid) that is obtained through the diet. It is found in all proteins and in artificial sweeteners. If PKU is not treated, phenylalanine can build up to harmful levels in the body, causing mental retardation and epilepsy. B. Both parents must be carriers of the gene for there to be a chance that the baby will have PKU. When two carriers conceive a child, there is a 25% chance that the baby will have the disorder. The incidence of carriers in the general population is approximately 1 in 50, but the chances that two carriers will mate are on 1 in 2500, bringing the incidence of affected people in the general population to 1 in 10,000. BODY I. Reducing the phenylalanine solely by restricting dietary protein from natural food would cause protein malnutrition and nutrient deficiency. Thus, such diets necessitate the use of phenylalanine-free amino acid formula containing adequate amounts of nitrogen, vitamins, minerals, and micronutrients. These dietary products have progressively been refined but

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