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Dynamics of Capillary Exchange Remember which side is filtration vs which is reabsorption Net filtration = (BHP+IFOP) - (BCOP+IFHP) CO = MAP/resistance IS THE SAME AS CO = heart rate x stroke volume MAP is measured in arterials Arterials control systemic vascular resistance Vascular Resistance (R) R is opposition of blood flow due to friction between blood and walls of blood vessels Depends on 3 things: Size of lumen Viscosity Blood vessel length MAP = diastolic BP + (1/3 [systolic BP - diastolic BP]) ex. 70 + 1/3 (110-70) = 83 MAP Cardiac accelerator nerves can increase rate and contractility Vagus nerve affect heart rate _____________________________________________________________ Renin-Aldosterone-Angiotensin (RAA) Stimulus: decreased blood volume, decreased blood flow to kidneys*** Who: juxtaglomerular cells in kidney What: secrete renin + enzyme ACE (angiotensin converting enzyme) Creates: angiotensin II (active form of angiotensin) Function: raises blood pressure Avenues: … via vasoconstriction, stimulates aldosterone secretion (increases reabsorption of sodium ions and water by the kidneys) *Results in an increase in blood volume, which raises blood pressure 2. Anti-diuretic Hormone (ADH) Stimulus: dehydration, decreased blood volume Who: Hypothalamus/released by posterior pituitary What: vasoconstriction (increased BP) Function: move water from lumen of kidney to blood stream (reabsorption) *Increase blood volume, decrease urine output ______________________________________________________________________ 3/18/2015 Immunity/Lymphatics *Lysozyme meaning and job (multiple choice) Body’s major physical barrier to microbes: skin The skin’s defense: macrophages Alternative complement pathway: between complement protein and microbe Skin and Mucous Membranes Chemical Defenses: Sebum, lysozyme, gastric juice

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