Neurobiological Theories

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Neurobiological Parallels of Co Occurring Psychiatric and Substance Use Disorders Karen M. Bates Walden University Biopsychology-PSYC-8226-2 November, 2010 Dr. Geoffrey Hutchinson Neurobiology of Co Occurring Psychiatric and Substance Use Disorders Depression, anxiety, and substance use have psychiatric symptomology overlap and the neurobiological similarities of these disorders are particularly active in neuroscience and neurobiology research (Brady, 2007). Despite the research, the mental illness-substance abuse dichotomy persists. Data indicates that individuals with co occurring disorders are inadequately served in both mental health and substance use treatment settings resulting in over-utilization of resources in the criminal…show more content…
Although, the MRI studies have been unable to produce statistically significant evidence in support of volumetric loss of brain mass, several theories associated with the serotonergic and noradrenergic synapses of the brain have prevailed in the neurobiological research literature associated with the etiological cause of depressive affective disorder. The theory historically most researched and prominent in the etiological studies of depression is the monoamine system theory. Evidence shows that monoamine inhibitors increase the levels of serotonin, tryptamine, and norepinephrine, the proteins that are present in the cytoplasm of the neuron of neurotransmitters that regulate mood, well-being and sleep leading to a focus on causes of underactivity of these synapses and receptors for these monoamines (Sourkes,…show more content…
Agonists work in enhancing the neurotransmitter by inhibiting reuptake of the chemical. Pharmaceutical or prescription drugs such as antidepressants facilitate in lowering the sensitivity of the presynaptic membrane, inhibiting the reuptake of serotonin, for instance, thus the recognition of the chemical in the neurons is not detected and the serotonin levels in the brain increases. The therapeutic effects are a decrease in depressed
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