Methotrexate Research Paper

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Methotrexate, Chemo Therapy Medication Annmarie Wallace Monroe College Professor, Morris 9/28/2012 In this research paper, I will be talking about a medicine named Methotrexate. Methotrexate has been used in the United States since 1953; it has been approved by the FDA to treat certain types of cancers. Since then, Medical researchers have discovered other important uses for this drug. Some of the important uses are Rheumatoid arthritis, psoriasis, and termination of pregnancy. This medicine works by making the immune system less active and suppressing the blood cells that cause inflammation. About Methotrexate- A person who has rheumatoid arthritis or Psoriasis often would be prescribed Methotrexate because this medicine will decrease…show more content…
An oral dose of 7.5 mg should be taken once per week for an adult who is treating rheumatoid arthritis or psoriasis, and it should be taken 2 hours before dinner or 2 hours after dinner. To determine what dose a child should take would be based on his/her weight. This medication is given four different ways orally, intravenously, intramuscular, and a spinal tap. If injecting Methotrexate the doctor would put the needle under the skin and inject 25mg per every milliliter. The advantages of having this medication injected is it works faster because it goes straight into the vein, the disadvantages is having to go to the doctor once a week to get the shot. People would rather take this medicine orally rather than injection because most people are scared of…show more content…
Health coverage does not cover the cost of Methotrexate. The research- A research was performed on 120 women treated with methotrexate therapy for unruptured tubal ectopic pregnancy. Sixty-two women received a single dose and 58 received a multiple dose methotrexate regimen. In the single dose group, treatment was considered successful in 50 women (80.6%), whereas in the multiple dose group, 52 women (89.7%) responded to treatment (p = 0.21; OR 0.90, 95%CI 0.77-1.05). The average number of days required for human chorionic gonadotropin (hCG) levels to fall below 5 mU/mL was longer in the single dose (22.3 +/- 7.6) compared with the multiple dose group (18.3 +/- 10.7) (p = 0.03). In the single dose group fewer or 17 women (24.7%) experienced side-effects compared to 28 (48.3%) of those who had multiple doses (p = 0.02, OR 0.57, 95%CI

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