Metabolism Essay

831 WordsAug 12, 20154 Pages
Metabolism Enzymes as Catalysts Enzymes are catalysts that work to drive a reaction forward producing a product of the substrate with the enzyme remaining unchanged. An enzyme has an active site where the substrate binds, creating the enzyme­substrate complex. When the enzyme comes into contact with the substrate, the active site induces a fit around the substrate and produces the product of the substrate. With an enzyme in a reaction, the activation energy necessary is lowered and the reaction is completed in the same amount of time. At the end of each enzyme­substrate complex, the enzyme is unchanged and able to bind to another substrate and begin the enzyme­substrate complex again. Sucrose is broken down to glucose and fructose. In the liver, fructose is acted upon by fructokinase producing fructose 1­phosphate. Then, aldolase B acts upon fructose 1­phosphate producing DHAP and glyceraldehyde. DHAP and glyceraldehyde can now enter the glycolysis pathway. Aldolase B Aldolase B is an enzyme primarily found in the liver. It is involved in the process of breaking down of fructose. It metabolizes the substrate fructose­1­phosphate to the products DHAP and glyceraldehyde. DHAP and glyceraldehyde enter into glycolysis which yields pyruvate or gluconeogenesis which yields G­6­P. If Aldolate B is not working correctly, Fructose­1­phosphate builds up using lots of phosphate and leads to a decrease in phosphate available. This is a problem because phosphate is depleted which is required by the electron transport chain to make ATP(Sanders, 2013). F­1­P acts as a signal of high blood sugar, causing glucokinase to stay in the cytoplasm. This makes abundant amount to G­6­P from glucose. Too much G­6­P causes gluconeogenesis and glycogen breakdown to slow down

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