Mache Essay

2313 Words10 Pages
GENERIC NAME | MECHANISM OF ACTION | INDICATION | CONTRAINDICATION | ADVERSE REACTION | NURSING CONSIDERATIONAND PRECAUTION | DigoxinBRAND NAMELanoxinCLASSIFICATIONCardiovascular drugsDOSAGETake with or without food. Adult and pedia >10 yrs: Rapid oral loading: 750-1500 mcg given bu mouth as single dose.Slow oral loading: 250-750 mcg daily for 1 week. | Inhibits sodium- potassium activated adenosine triphosphate, thereby allowing influx of calcium into the intra cellular space (cytoplasm), more available calcium promotes increased force of myocardial contraction (positive inotrophic effect) resulting to increased cardiac output. It also acts on the CNS to enhance vagal tone, causing the decrease of conduction speed between the SA and AV nodes. This vagal stimulation decreases the cardiac rate (negative chronotropic effect) to prevent arrhythmia. | Chronic cardiac failure with atrial fibrillation, ventricular dilatation, supraventricular arrhythmias. | Intermittent complete heart block or 2nd degree atrioventricular block especially with history of Stokes- Adams attack; Woff- Parkinson- White syndrome; hypertrophic obstructive cardiomyopathy; hypersensitivity. | * Anorexia * Gastrointestinal disturbances * Central nervous system effects * Atrial tachycardia * Gynecomastia | * Assess apical pulse for 60 secs (30 secs if on maintenance therapy). If pulse is <60/min (<70min for children), withhold drug, contact physician. * Blood samples are best taken 6-8 hours after dose or just before next dose. * May be given without regard to meals. * Tablets may be crushed. * Monitor pulse for bradycardia, EKG for arrhythmias for 1-2 hours after administration (excessive slowing of pulse may be a first clinical sign of toxicity). * Assess for GI disturbances, neurologic abnormalities (signs of toxicity) every 2-4 hours during digitalization

More about Mache Essay

Open Document