Intermountain Risk Score

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The Intermountain Risk Score (Including the Red Cell Distribution Width) Predicts Heart Failure and other Morbidity Endpoints Benjamin D. Horne, Heidi T. May, Abdallah G. Kfoury, Dale G. Renlund, Joseph B. Muhlestein, Donald L. Lappé, Kismet D. Rasmusson, T. Jared Bunch, John F. Carlquist, Tami L. Bair, Kurt R. Jensen, Brianna S. Ronnow, Jeffrey L. Anderson Eur J Heart Fail. 2010;12(11):1203-1213. Abstract and Introduction Abstract Aims The complete blood count (CBC) and basic metabolic profile are common, low-cost blood tests, which have previously been used to create and validate the Intermountain Risk Score (IMRS) for mortality prediction. Mortality is the most definitive clinical endpoint, but medical care is more easily applied to…show more content…
Although mortality is the most definite and final of medical outcomes,[2] many physicians are hesitant to calculate patient mortality risk in the absence of other morbidity risk information. To further elucidate its utility and applicability among non-mortality endpoints, this study applied the mortality prediction IMRS models to evaluate the association with heart failure (HF), myocardial infarction (MI), coronary artery disease (CAD), atrial fibrillation (AF), and other morbidities and risk factors that may lead to death. Methods Study Populations and Endpoints This study's primary aim was to discover morbidity endpoints predicted by the IMRS that are potentially modifiable through lifestyle changes or medical treatments. The study was designed similar to a genome-wide association study with many tests of hypothesis whose significance is conservatively corrected for multiple comparisons and the results of which are replicated in a similar, larger, independent population. Patients undergoing coronary angiography between October 2005 and December 2007 (n = 3927), at LDS Hospital (Salt Lake City, UT, USA), McKay-Dee Hospital (Ogden, UT, USA), and Intermountain Medical Center (Murray, UT, USA) who were enrolled into the database registry of the Intermountain Heart Collaborative Study[3] were evaluated for 30-day and 1-year death using previously defined risk categories.[1] A second population of patients undergoing coronary angiography between October 1993 and April 2005 (n = 10 413), from only LDS Hospital (Intermountain's flagship hospital until October 2007) was utilized to validate the associations discovered in the first population. This study was approved by the Intermountain Healthcare Institutional Review Board. Primary disease endpoints studied herein included HF, MI,

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