Inflammation In Alzheimer's Disease

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Alzheimer disease is something that is a serious disease it is commonly find in elderly adults and is caused by dementia it is characterized by a major loss of memory and many more cognitive functions. Histopathologically is seen as a presence of neurotic plaques and neurofibrillary tangles. Inflammation in Alzheimer disease, the immune system plays a very important role to development of Alzheimer disease it has a unclear role and it still needs to be understood which part of the immune system might be damaged, Failure may lead to chronic inflammation, which is known as part of the pathology in the brain of individuals with Alzheimer's disease. No one knows exactly how Alzheimer develops yet, there has been many clues as to why it happens.…show more content…
Senile neuritic plagues are small circler looking objects. They are amyloid protein martial composed of residue left from a nerve that the ends are broken off and decaying. The presences near the cell are indication’s that something is wrong. A Neutric plaque is by far the best evidence for diagnostic to make a decision if a person has Alzheimer’s disease. A third sign is granulovacuolar degeneration, this is when the fluid-filled vacuoles are crowing inside the nerve cell. This condition is can only be observed in a careful sliced and analyzed brain tissue. However the cell having lost all its dendrites and nucleus the disintegrates vanish into the body waste system. With the depletion of nerve material the brain is actually shrinking and sometimes as much as ten perfect. The cells that Alzheimer Disease suffers from the more mental function the person loses, and soon the person will have little to no motor skills. Many people who are quick on their quick and active moving, they were reduced to the mental status of a…show more content…
Imaging-based measures of disease progression in clinical trials of disease-modifying drugs for Alzheimer disease. Am J Geriatr Psychiatry. [2]Silbert LC, Quinn JF, Moore MM, et al. Changes in premorbid brain volume predict Alzheimer’s disease pathology. Neurology. 2003;61:487–492 [1]Minoshima S, Frey KA, Koeppe RA, et al. A diagnostic approach in Alzheimer’s disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. J Nucl Med. 1995;36:1238–1248. [2]Senescence-accelerated OXYS rats: A model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease. (2013). Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Schloss Birlinghoven Linking Hypothetical Knowledge Patterns to Disease Molecular Signatures for Biomarker Discovery in Alzheimer's Disease. (2014). Small Molecule Discovery Platform, Molecular Therapeutics Program. Center for Applied Medical Research CIMA, University of Navarra, Pamplona,

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