Grt Task 4 Wgu

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Biochemistry 208.5.4-01 Case 1 involves a five month girl whose symptoms include vomiting, dehydration and unexplained fever. She exhibits symptoms of excessive urination and sweating as well. These symptoms began per the parents report when the child began drinking juice and baby food fruits. The baby shows a loss of appetite and appears to be growing slower than other children. Upon examination her liver is swollen and eyes are indicative of jaundice. Liver and kidney profiles indicate a decrease of function. The medical provider has given a diagnosis of HFI(hereditary fructose intolerance). Hereditary fructose intolerance is an autosomal recessive disorder and it involves the body lack of Aldolase B to break down the fructose in the liver, kidney and intestine. Aldolase B is considered the chief aldolase isoenzyme that is responsible for fructose metabolism and gluconeogenesis within the liver. This is turn, produces fructose 1,6-biphosphate from the glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. When fructose is ingested, the body cannot change its energy storage substance glycogen to glucose. When glucose builds up in the liver, the blood sugar falls resulting in hypoglycemia. (PubmedHealth, 2009) Fructose 1 phosphate which is the substrate of Aldolase B is split by Aldolase. This splitting is done by the lock and key design because the fructose 1 phosphate fits into the aldolase. The lock and key model enables the molecules called substrates to go through chemical changes to form new substances called products. Substrates are what enzymes act upon. Each substrate fits into an area of the enzyme and is called active sites. The way these fit together is consistent with a lock and key method even though the enzyme changes shape to

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