Title: Org 2.12 – Synthesis Reactions with Carbonyl Compounds – The Grignard Reaction Introduction: Grignard reagents are very useful compounds in organic chemistry. They are named after the French chemist, Francois Auguste Victor Grignard. He discovered them in 1900 and was awarded the Nobel Prize in Chemistry in 1912 for his work (1). Grignard reagents belong to the family of compounds known as organometallics – organic compounds that contain at least one carbon-metal bond in their structure (2). They are prepared by reacting magnesium turnings with an alkyl halide or an aryl halide, usually in ether solvent.
Athena Cochinamogulos Dr. Miller Organic Chemistry II October 23, 13 Title: Suzuki Palladium Cross-Coupling Reaction: Synthesis of 4-Acetyl-4-methyldiphenyl Abstract: In this experiment, the Suzuki Cross coupling reaction between 4-methylphenylboronic acid and 4-bromoacetophenone was utilized to prepare 1-(4’methyl-biphenyl-4-yl) ethanone. Purification through vacuum filtration was carried out and rotary evaporation was executed. The characterization of the purified product was determined by comparing its spectra and melting points to those presented in the literature. The melting point of the product was 58-70°C; which largely differs from the literature value suggesting impurities but the use of spectra data allowed for the determination of product and overall experimental successful. Reaction Equation: Introduction: An organic reaction of an aryl- or vinyl-boronic acid with an aryl- or vinyl-halide catalyzed by a palladium (0) complex or by a palladium nanomaterial-based catalyst describes the Suzuki reaction first reported by Miyaura, Yanagi, and Suzuki in 1981.
Experiment 2.13.: Micro-scale Synthesis of Triphenylmethanol Aim: This was a two part experiment in which the aim of the first part was to synthesise the Grignard reagent phenylmagnesiumbromide from reacting bromobenzene with magnesium and diethyl ether. The aim of the second part was to synthesise the alcohol triphenylmethanol using the previously produced phenylmagnesiumbromide by reacting it with benzophenone. Introduction: This experiment involved two reactions. First the Grignard reagent, phenylmagnesiumbromide, was synthesised from bromobenzene, magnesium and diethyl ether. Once produced, the Grignard reagent was then used to synthesise triphenylmethanol by reacting it with benzophenone.
Another bottle from the same laboratory is labeled “Compound B (isomer of A).” Compound B also reacts with 1 mol equiv of hydrogen, but yields cyclohexanone after treatment with acidic [pic]. a. Suggest structures for A and B. Answer: b. What was the other product formed in the [pic] oxidation of B?
The mass was recorded and transferred to a 50 ml beaker. 4 ml of 6 M HNO3 was added to the beaker containing the copper. For step 2, 10 ml of distilled water was added to the beaker. Then, 6 M NaOH was added to the solution (drop wise), until placing a drop of the solution on red litmus paper turned it blue. For step 3, the solution was heated with a hot plate.
Methlyene chloride was a good solvent in this case because its boiling point is 40 degrees C and will boil off before the trimyristin which has a boiling point of 56-57 degrees C. Finally acetone was added to wash the crystals and the solution was vacuum filtered. This process was repeated and the trimyristin was collected. Results: Experimental yield of trimyristin= .64g Experimental melting point of trimyristin= 59 degrees C Percentage yield = experimental-truex100 True Dicussion: The extraction of trimystrin left white crystals resembling a powder. Its melting point was 56 degrees C which was exactly the recorded value. However, given that
Urea is an organic compound with the chemical formula (NH2) CO 2. It is highly soluble in water and therefore, a good way for the human body to expel excess nitrogen.Cinnamic acid has the formula C6H5CHCHCOOH; is a white crystallin acid slightly soluble in water. Materials: This lab consisted of two solid organic compounds Urea and Cinnamic acid. It also consisted of the Mel-temp, a pestle, a spatula, a balance weighed in mg, and tubes to put the organic compounds in. Procedures: First, we were each assigned a group number.
LIQUID-LIQUID EXTRACTION OF BENZOIC ACID J Wright Organic Chem Lab 1 Tuesday 1:40-5 Ian Stubbs LIQUID-LIQUID EXTRACTION OF BENZOIC ACID PURPOSE: The purpose of this experiment was to extract benzoic acid from an aqueous of benzoic acid using methylene chloride, use liquid-liquid extraction to calculate the distribution coefficient of benzoic acid and to determine whether a single extraction or multiple extractions are more efficient. Add in the table of physical constants. See the attachment for the lab format. PROCEDURE: Gather a two stock solution that includes; 0.02M of sodium hydroxide (NaOH) aqueous solution and 0.02M of benzoic acid aqueous solution. For a single extraction, use a 50mL graduated cylinder and measure out 50mL of the benzoic acid solution into a 125mL separatory funnel.
They were glucose, water, lemon juice, Coca Cola, egg batter, lemon-lime soda, diet lemon-lime soda, Kraft Italian dressing, skim milk and butter. The positive control was the glucose and the negative control was the water. Twenty drops of each sample of substance was added to the test tubes (in all there were 10 test tubes). After the solutions were added in their own test tube, 20 drops of Benedict’s reagent was added. Each individual test tube was placed in boiling water and removed after 5 minutes to test if