Epstein Barr Virus Essay

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Epstein Barr Virus Stacey Espinosa Ms. Silva Microbiology M,W 6:30-9:20 pm Feb. 27, 2013 Abstract Introduction One of the most common viruses in humans is the Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), a virus of the herpes family. One of the many questions of herpesvirology is why a herpesvirus is so recklessly wasteful in its use of four or more envelope glycoproteins for entry into a cell when other viruses can manage very well with only one or two. Wastefullness does, however, have its advantages. Epstein-Barr virus (EBV), originally recognized for its ability to infect and transform lymphocytes, is now clearly understood to infect epithelial cells as part of its normal cycle of persistence in a human host, and under some circumstances, the virus may infect T cells, natural killer cells, smooth muscle cells, and possibly monocytes as well. Our understanding of how EBV enters each of these cell types is very incomplete, but some of the major players involved in B-cell and epithelial cell infections are being identified, and they provide a window into the flexibility of tropism that the use of different combinations of virus and cell membrane proteins can provide. It is best known as the cause of infectious mononucleosis (glandular fever). Infectious mononucleosis is a systemic disease of viral origin that involves the lymph nodes, spleen, liver, skin and has occurred in less than 1% of central nervous system (CNS) infections. Such as, meningitis, encephalitis, cerebellitis, transverse myelitis, opyiv neuritis, cranial neuropathy, Guillain-Barre syndrome, or as a small fibersnesory ot sutonomic neuropathy syndrome (Rowland & Pedley, 2010) (Bradley, 2004). It is also associated with particular forms of cancer, such as Hodgkin's lymphoma, Burkitt's lymphoma, nasopharyngeal carcinoma, and central nervous system lymphomas

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