Epithelium Essay

5333 Words22 Pages
------------------------------------------------- أعلى النموذج Advanced search أسفل النموذج * Follow us Help & Contact * Journals & books * Online tools * Authors, editors & reviewers * About Elsevier * Community * Store Experimental Cell Research * Guide for Authors * Submit Your Paper * Track Your Paper * Order Journal * View Articles * Open Access Options * Most Downloaded Articles * Journal Insights * Recent Open Access Articles * News * Most Cited Articles * Special Issues * Recent Articles * Conferences Stay up-to-date Register your interests and receive email alerts tailored to your needs Click here to sign up Follow us Share on twitter Most Downloaded Experimental Cell Research Articles The most downloaded articles from ScienceDirect in the last 90 days. 1. Hallmarks of cancer: Interactions with the tumor stroma 1 May 2010 Kristian Pietras | Arne Östman Abstract: Ten years ago, Hanahan and Weinberg delineated six “Hallmarks of cancer” which summarize several decades of intense cancer research. However, tumor cells do not act in isolation, but rather subsist in a rich microenvironment provided by resident fibroblasts, endothelial cells, pericytes, leukocytes, and extra-cellular matrix. It is increasingly appreciated that the tumor stroma is an integral part of cancer initiation, growth and progression. The stromal elements of tumors hold prognostic, as well as response-predictive, information, and abundant targeting opportunities within the tumor microenvironment are continually identified. Herein we review the current understanding of tumor cell interactions with the tumor stroma with a particular focus on cancer-associated fibroblasts and pericytes. Moreover, we discuss emerging fields of research which need to be further explored in order to
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