Effects of Morphine on Transgenic Mice Essay

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The purpose of this article was to retest the assumption that lidocaine inhibits the release of neuropeptides from sensory nerve terminals in rats. Previous studies had controversial results concerning the response elicited from intracutaneous lidocaine injections versus the lidocaine injections affecting visceral organs which in turn possibly caused a neurogenic inflammation. One confound of this experiment was the pretreatment of lidocaine which magnified the response of inflammation. Histamine, mustard oil, or a dye known as Compound 48/80 was also injected intracutaneously in the same region as the lidocaine to better show a dye leakage response elicited from the lidocaine; histamine elicited a magnified response of inflammation as well. The results of this experiment revealed that it is unlikely that lidocaine inhibits the response from sensory nerve endings and suggests that lidocaine possibly effects endothelial function. This experiment was used to study the effects of lidocaine on sensory nerve endings and whether these effects lead to neurogenic inflammation that was noticed in previous human subjects. In doing so, experimenters sought to understand if the reaction was caused on an intracutaneous level or if it was the result of an endothelial function. I don’t think I know enough background to understand why certain stains were used such as mustard oil, Compound 48/80, or the histamine reactive but from this experiment the mustard oil showed the greatest response according to Figure 1. I think the ethical concern arises as these rats bled to death as a result of experimentation with lidocaine, which I thought was an anaesthetic not intended to induce

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