Effectiveness of Hydroxyurea / Sickle Cell

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Effectiveness of Hydroxyurea for the treatment of Sickle Cell Anaemia Problem Sickle-cell disease or sickle cell anaemia is a hereditary blood disorder. Sickle cell disease is a genetic disorder that decreases life expectancy by 25 to 30 years. Patients with sickle cell disease experience both chronic and episodic pain and have a reduced quality of life. Rather than the blood cell being round and flexible, the sickle red blood cells become shaped like a crescent or sickle, hence the name. Sickle cell trait occurred as a natural mutation of the haemoglobin gene. Sickling decreases the cells' flexibility and results in a risk of various complications. (2) The sickling occurs because of a mutation in the haemoglobin gene. The cause is inherited. Sickle-cell anaemia is a form of sickle-cell disease in which there is homozygosity for the mutation that causes HbS. The inherited abnormality causes a pathological condition that can lead to death and severe complications. Sickle-cell disease occurs more commonly among people whose ancestors lived in tropical and sub-tropical sub-Saharan regions where malaria is common. Where malaria is common, carrying a single sickle-cell gene (sickle cell trait) confers a fitness. Specifically, humans with one of the two alleles of sickle-cell disease show less severe symptoms when infected with malaria. (2) Sickle-cell anaemia is a form of sickle-cell disease in which there is homozygosity for the mutation that causes HbS. Sickle-cell anaemia is also referred to as "HbS". In heterozygous people, that is those who have only one sickle gene and one normal adult haemoglobin gene, the condition is referred to as "HbAS" or "sickle cell trait". Sickle cell anaemia causes an oxygen deficiency in different parts of the body, if developing cells do not receive enough oxygen, their growth can be stunted. The abdominal and chest pain

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