Effect If Infliximab on Ulcerative Colitis Essay

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Is Infliximab an effective treatment in inducing and maintaining remission in Ulcerative Colitis? Ulcerative Colitis is a form of inflammatory bowel disease. It is a chronic illness which affects the colon (large intestine). The colon is the last past of the digestive system (see Figure 1). It is a three to five feet long thick muscular organ and has an inverted U shape. The colon receives waste products from the small intestine through the ileocecal valve. Peristalsis (muscular wavelike motion) moves the waste products forward through the colon. The colon absorbs the nutrients and water from those waste products and eliminates them from the body in the form of faeces through the rectum and the anus. Ulcerative colitis is the inflammation of the colon and in many cases ulcers or painful sores form on the lining of the colon (see Figure 2). If the ulcers are aggravated they may bleed and produce mucus and pus. (1) Figure 1- Human digestive system Figure 2- A colon affected by Ulcerative Colitis Ulcerative Colitis was at first difficult to distinguish from infectious diarrhoea and dysentery which produced similar symptoms and was common before a reliable supply of clean water became available. The first description of Ulcerative Colitis was made by an Englishman named Wilks in 1859. It is an uncommon condition and 10 new cases are made every year per 100,000 people. It is estimated that currently 100,000 people in England suffer from this condition. The condition can affect any age group but normally peaks itself between the age of 15 and 30. It is more common among white people of European descent particularly descendants of Ashkenazi Jewish community (Jews who lived in Eastern Europe and Russia) and black people. It is rarer in Asian communities. Both males and females are equally affected by Ulcerative Colitis. Symptoms Ulcerative Colitis is a

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