Dmard's Essay

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DMARD’s stands for disease modifying antirheumatic drug, according to WebMD there are many variations of arthritis medications called disease-modifying antirheumatic drugs, or DMARDs, that work by curbing the underlying processes that cause certain forms of inflammatory arthritis including rheumatoid arthritis (RA), ankylosing spondylitis, and psoriatic arthritis (WebMD, 2015). The pharmacodynamics of DMARD’s especially with the use of methotrexate side effects include upset stomach and a sore mouth. Methotrexate can interfere with the bone marrow's production of blood cells. Low blood cell counts can cause fever, infections, swollen lymph nodes, and easy bruisability and bleeding. Liver or lung damage can occur, even with low doses, and, therefore, requires monitoring (Schur, 2013). The pharmacotherapeutics of DMARD’s are to focus on reducing this disease and its progression. The two key themes supported by research and clinical experience is to treat early and aggressively DMARD monotherapy or combination therapy. Secondly, tight control or treating into remission (primeinc.org). Tight control would consist of disease activity and prognosis have been established, providers should begin treatment with DMARDs, following treatment algorithms recommended by the ACR guidelines. Treatment should be managed to a goal of tight control. Tight control of RA is defined as aggressive medical management with early initiation of DMARDs and quarterly visits with a rheumatologist (Murphy, Newsome & Galdo,2014). There are five main drugs used to treat RA these drugs are DMARD’s, Biologic response modifiers, Glucocorticoids, NSAIDs & Analgesics (WebMD, 2015). According to primeinc.org updated guidelines for guidelines suggest that patiently recently diagnosed should be treated with synthetic DMARD monotherapy. The standard first-line is methotrexate administered orally or

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