Corticosteroids Case Study

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Index: Corticosteroids p. 2 Corticosteroids and Systemic Lupus Erythematosus p. 2-3 Polybrominated biphenols p. 3-4 Bisphenol A p. 4-5 Dichlorodiphenyltrichloroethane (DDT) p. 5-6 Alkylphenols p. 6 References p. 7-8 Corticosteroids According to NHS choices a corticosteroid is a chemical hormone that is produced in the adrenal cortex. NHS choices also indicate the following functions for corticosteroids: regulates the immune system, regulates the balance of salt and water in the body, regulate the body’s metabolism and helps with normal process of sexual function. (NHS choices, 2013) Corticosteroids are used as anti-inflammatories to reduce inflammation, immunosuppressants, and as therapy to replace…show more content…
(Zeratsky, K., 2013) This chemical causes health problems with regards to brain disorders and behavioural problems in children. (Zeratsky, K., 2013) BPA is found in epoxy resin like bottle tops, dental sealants, food cans and water pipes as well as polycarbonate plastic like water bottles and plastic containers. (Zeratsky, K., 2013) BPA is identified by codes 3 or 7 on plastic recycle marks. (Zeratsky, K., 2013) Research shows that BPA levels increase when plastic breaks down, resulting in the release of BPA into food and drinks. (Zeratsky, K., 2013) Even if BPA levels are low, it can still impair normal bodily functioning. (Lyons, G., 2000) BPA as an endocrine disruptor, mimics estrogen. (Lyons, G., 2000 and Ruben, B., 2011) In the body there is more estrogen than estrogen mimics. (Matisová, E., 2012) However, because the estrogen attaches itself to sex-hormone proteins in the blood this results in less estrogen than estrogen mimics, as the latter cannot bind with sex-hormone proteins. (Matisová, E., 2012) The BPA then affects the endocrine-related pathways by first attaching itself to estrogen receptors in cells (Ruben, B., 2011 and Matisová, E., 2012). Secondly, it mimics or blocks the body’s actual estrogen action and metabolism (Lyons, G., 2000 and Matisová, E.,…show more content…
(IPIC, 1999 and Cruising chemistry) • As a pesticide in industrial areas (Cruising chemistry) • To eliminate pests from eating food crops on farmlands (Science Clarified) DDT enters the body through breathing or eating polluted DDT food. (MDhealth.com, 2015) and damages the body in 3 ways: A: - As a lipid soluble, it gets stored in fatty tissues of the endocrine systems. (Science Clarified and Cruising science) - Gathering in the testes, thyroid and adrenals. (Cruising science) - The measure of fat in humans will determine how much DDT gets stored. (Cruising science) - High concentration DDT is found in human milk. (Cruising science) - The kidneys and liver stores lower concentration DDT. (Cruising science) - Once DDT is in the hormone it then acts as an estrogen mimic. (Cruising science and MDhealth.com, 2015) B: - DDT also enters the plasma membrane due to its lipid solubility. (MDhealth.com, 2015) - This causes cell leaking of sodium and potassium ions. (MDhealth.com, 2015) - The nervous system gets damaged, due to the ion change. (NPIC, 1999 and MDhealth.com)

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