Cori Cycle Essay

1814 WordsApr 28, 20158 Pages
Hereditary Fructose Intolerance [Customer’s Name] [University Name] [Course Name] Hereditary Fructose Intolerance Introduction Enzymes are the biological catalysts which are proteins in nature. There are two properties of enzymes which make them to be used as catalysts in biological reactions. One, enzymes catalyze the reactions without any change in the nature of enzyme itself. Two, enzymes boost up the speed of biological reactions without changing the equilibrium of reactants and the products (Cooper, 2000). In the absence of enzymes, the biological reactions may prolong for hours or even would not occur at all. Since, enzymes play a critical role in biological reactions, any change or absence of enzymes may lead to complex diseases. Hereditary Fructose Intolerance (HFI) is an autosomal recessive genetic disorder which disables the production of an enzyme, Aldolase B. Aldolase B is an isozyme of the enzyme aldolase which is used in catalytic reactions in gluconeogenesis, glycolysis and fructose metabolism. The catalysis of fructose occurs in liver and whole of the fructose is broken down in liver cells only. The final products of fructose metabolism leads to the production of dihydroxyacetone phosphate and glyceraldehyde which are further used up to form liver glycogen and triglycerides (Steinmann & Santer, 2012). Fructose Metabolism The first step in fructose metabolism is the formation of fructose- 1- phosphate from fructose by phosphorylation. The enzyme which catalyzes the phosphorylation is fructokinase. In the second step, fructose- 1- phosphate adolase or aldolase B enzyme catalyzes the hydrolysis of fructose- 1- phosphate into the products, i.e., dihydroxyacetone phosphate (DHAP) and glyceraldehyde (Van Den Berghe, Bronfman, Vanneste, & Hers, 1977). The substrate for the enzyme aldolase B or aldolase is actually fructose- 1- phosphate and

More about Cori Cycle Essay

Open Document