Chem Lab Essay

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CHEM 51LC Page 1 Rev 04 /30 /1 3 C HEM 51LC E XP # 6 S PRING 201 3 S YNTHESIS OF A SPIRIN REACTIONS: Hydrolysis of an ester and esterification of an alcohol In Part A of this experiment, you will do a base - promoted hydrolysis of the ester in wintergreen oil to convert it into salicylic acid. Purity will be evaluated using melting point analysis. In Part B , you will esterify your newly generated salicylic acid usin g acetic anhydride to form acety lsalicylic acid, also known as a spirin. Again, purity will be determined via melting point. READING ASSIGNMENT: ● This handout for procedure . ● Supplementary information in Janice Gorzynski Smith (2 nd ed), Chapter 22.11 PRE - LAB ASSIGNMENT : ● Complete all portions of pre - lab notebook work according to the guidelines. ● Rewrite the procedure in your lab notebook using your own words. ● Sapling assignment. CHEM 51LC Page 2 Rev 04 /30 /1 3 CAUTION Sodium hydroxide is corrosive and causes burns. Wear gloves and avoid all contact with skin, eyes, and clothing. Notify the TA if any solid NaOH is spilled. Sulfuric acid solutions are corrosive and cause burns. Wear gloves and avoid all contact with skin, eyes, and clothing. Methyl salicylate is toxic and an irritant. Wear gloves and avoid all contact with skin, eyes, and clothing. Salicylic acid is toxic and an irritant to skin, eyes, mucous membranes, and the upper respiratory tract. Avoid breathing the dust. Avoid all contact with skin, eyes, and clothing. EXPERIMENTAL: Add 4.7 mL H 2 O and 0.65 g NaOH to a 10 mL roundbottom containing a stirbar and stir until the solid is dissolved. Add 0.27 mL methyl salicylate to the roundbottom. A white solid may or may not suddenly appear. Reflux the solution for 15 minutes using a sand bath. Re move the roundbottom from the sand bath and allow

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