Biological Explanations For Schizophrenia Essay

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Describe and evaluate biological explanations for schizophrenia: Genetics have been identified as one possible explanation for schizophrenia. For instance, Miyakawa studied DNA from human families affected by schizophrenia and found that those with the disease were more likely to have a defective version of a gene, called PPP3CC which is associated with the production of calcineurin which regulates the immune system. Also, research by Sherrington has found a gene located on chromosome 5 which has been linked in a small number of extended families where they have the disorder. Family studies investigate genetic transmission of schizophrenia; studies compare rates of schizophrenia in relatives of diagnosed cases compared to relatives of…show more content…
Family, twin and adoption studies must be considered cautiously because they are retrospective, and diagnosis may be biased by knowledge that other family members who may have been diagnosed, suggesting there may be problems of demand characteristics. A second weakness is the problem of nature-v-Nurture. It is difficult to separate the influence of nature-v-nurture. The fact that the concordance rates are not 100% means that schizophrenia cannot wholly be explained by genes and it could be that individuals have a pre-disposition to schizophrenia. This suggests that the biological account cannot give a full explanation of the disorder. A final weakness of the genetic explanation of schizophrenia is that it is biologically reductionist. The Genome Project has increased understanding of the complexity of the gene. Given that a much lower number of genes exist than anticipated,it is now recognised that genes have multiple functions. Schizophrenia is a multi-factorial trait as it is the result of multiple genes and environmental factors. This suggests that the research into gene mapping is oversimplistic as schizophrenia is not due to a single
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