Antimicrobial Peptides Research Paper

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Introduction In this essay I will be looking at Antimicrobial Peptides. They are membrane active polypeptides which have an important role in the defence system of a living organism. Antimicrobial Peptides(AMPs) are a unique and diversified group of molecules produced by all types of living organisms. Antimicrobial Peptides are considered to be part of all living organisms natural immunity1. Identification and structure Antimicrobial Peptides have antibacterial characteristics that kill viruses, bacteria (gram positive and gram negative), protozoa, and fungi. They are small, positively charged, amphipathic molecules (which have both hydrophobic and hydrophilic regions) of variable amino acid configuration 2 . Their mode of action can vary…show more content…
Cationic peptides are the first to be discovered and are widely found in plants and animals. Anionic peptides are a smaller group of molecules which show antimicrobial action and have been up until now only isolated from mammals. Prokaryote antimicrobial peptides are produced by bacterial cells.The most important active-membrane peptides among them are created by gram-positive bacteria and are identified as bacteriocins6. Antimicrobial Peptides in the Pharmaceutical Industry Antimicrobial resistance (AMR) is a threat to the health of the population of the planet. AMR is present in all continents of the world and as new resistance mechanism emerge they spread across the world. This is a very serious issue as the treatment of bacteria, parasites, viruses and fungi is not effective as the strains are evolving and showing resistance to antibiotics as well as other drugs7. The action of the antimicrobial peptides in a living organism is considerable as the fact that the resistance of microorganisms toward antibiotics has grown. Antimicrobial peptides have since attracted attention as an alternative to antibiotics. They have also been identified to be used in conjunction with…show more content…
Two substances were discovered which he called “Magainins”. Magainins means shield in the hebrew language13. In 1999 Magainin Pharmaceuticals were denied FDA approval for Pexiganan(commercial API name for Magainins). The approval was not granted due to GMP deficiencies. The FDA main concern was in the formulation mainly water separation. The dosage form is a topical cream. However Dipexium Pharmaceuticals which were founded in 2010 have now made a second submission for the drug which if approved will be called Locilex and will be used to treat patients with diabetes who have mild infectious foot ulcers. Advancements in manufacturing techniques have made this submission possible. In 2015 Dipexium will carry out placebo trials and are confident of positive results as in over 500 patients treated to date Locilex has shown to be safe, no bacterial resistance and no systemic
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