The Incidence of AIDS – Defining Illnesses in 4883 Patients With Human Immunodeficiency Virus Infection
Amanda Mocroft, PhD; Michael Youle, MBChD; Andrew N. Phillips, PhD; Ramesh Halai; Phillipa Easterbrook, MD; Margaret A Johnson, MD; Brian Gazzard, MD; for the Royal Free/Chelsea and Westminster Hospitals Collaborative Group
AIDS is a very devastating disease that does not have a definitive cure. AIDS is an Acquired Immunodeficiency Syndrome (AIDS) defining illness known to occur in different levels of immunosuppression. After reading the article I did locate all of the steps of the scientific method. The observation of this experiment was between 1982 and 1995, 4883 patients testing positive for human immunodefiencey virus were seen at either Royal Free or Chelsea and Westminster Hospitals in London, England. Hypothesis of this experiment is if using prophylaxis that will help cut down the number of patients who acquire AID’s. The experimental design of this experiment was very complex. The incidence of the disease has often been quoted as a proportion of patients who developed disease within 1 or 2 years of the CD4 lymphocyte count dropping below some arbitrary levels. CD4 lymphocyte is a specific type of lymphocyte, derived from the thymus gland, which plays an important role in cellular immunity. T4 lymphocytes (CD4 cells) are decreased (absolute counts less than 200) in patients with AIDS resulting in compromised immune function. This allowed the doctors to eliminate people who had passed away or there CD4 lymphocyte had significantly dropped. The data collection in this experiment was very comprehensive. During a 10 year time period comprehensive data on more than 4500 patients infected with human immunodeficiency virus (HIV), of whom 2500 were patients with AIDS, were collected. The results of this study were to determine CD4 lymphocyte counts at which AIDS-defining illnesses were diagnosed in England. Also to investigate changing...