Exogenous And Endogenous Pacemakers In Biorhythums

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Discuss the role of exogenous and endogenous pacemakers in biological rhythms: Endogenous: Most organisms have an internal biological ‘clock’ which controls the circadian rhythm. Your biological clock is endogenous (part of the internal organism). Biological clock helps us to realise an event, for example when it is night time. Darlington et al (1998) said that the ticking of the clock is created by reactions between proteins. He described it as continuous circle; Proteins ‘CLOCK & CYCLE’ bind together in the morning, which increases the production of ‘PER & TIM’ during the day. As these increase, the production of ‘CLOCK & CYCLE’ decrease. As they decrease, production of ‘PER & TIM’ fall and ‘CLOCK & CYCLE’ increase, ready for the cycle to begin again for a new day. The main endogenous pacemaker is found in the hypothalamus. The SCN is a pair of tiny clusters of nerve cells. They are located just above where the optic nerves from each eye cross over (optic chiasm). The SCN obtains information on light from the optic nerve even when the eyes are shut. Special photoreceptors in the eyes pick up light signals and carry them to the SCN. If our endogenous clock is running slow (i.e. sun rises earlier than day before), the morning light automatically shifts the clock ahead. So your rhythm is in step with the world outside. The importance of the SCN is suggested by Decoursey et al (2000), who found that if the SCN is damaged or removed from an animal, then sleep-wake patterns are affected. This explanation for the role of the SCN is reliable. Morgan bred “mutant” hamsters so they had circadian rhythms of 20 hours instead of 24 hours and then transplanted their SCN’s into normal hamsters. He found that the normal hamster displayed the mutant rhythms. Therefore, this implies there is strong evidence to support the theory. However, there
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