Reflective Journal Essay

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Interval between breast-conserving surgery and start of radiation therapy in early-stage breast cancer is not predictive of local recurrence: a single-institution experience.
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Authors:
Barbieri V; Sanpaolo P; Genovesi D
Author Address:
Radiation Oncology Department, Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Italy. vbarbie76@yahoo.it
Source:
Clinical Breast Cancer [Clin Breast Cancer] 2011 Apr; Vol. 11 (2), pp. 114-20. Date of Electronic Publication: 2011 Apr 11.
Publication Type:
Evaluation Studies; Journal Article
Language Code:
eng
Journal Information:
Country of Publication: United States NLM ID: 100898731 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-0666 (Electronic) Linking ISSN: 15268209 NLM ISO Abbreviation: Clin. Breast Cancer Subsets: MEDLINE
MeSH Terms:
Mastectomy, Segmental*/rehabilitation
Breast Neoplasms/*radiotherapy
Breast Neoplasms/*surgery
Carcinoma/*radiotherapy
Carcinoma/*surgery
Combined Modality Therapy/*methods
Neoplasm Recurrence, Local/*diagnosis
Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Carcinoma/diagnosis ; Carcinoma/pathology ; Disease-Free Survival ; Female ; Humans ; Middle Aged ; Neoplasm Staging ; Prognosis ; Radiotherapy, Adjuvant ; Retrospective Studies ; Time Factors
Abstract:
Background: The aim of this study was to evaluate if the interval between breast-conserving surgery and the start of radiotherapy has an effect on local relapse risk.
Materials and Methods: Between January 2000 and December 2006 a total of 387 patients with T1-2N0+ breast cancer were treated with breast-conserving surgery and radiotherapy, with and without hormone therapy and chemotherapy. Adjuvant radiotherapy was administered to a total dose of 60 to 66 Gy in 30 to 33 fractions. The time intervals between...