Acute pancreatitis rarely complicates pregnancy. Although most pregnant women with acute pancreatitis have associated gallstones, less common causes such as drugs have been reported.
We report the case of a 34-year-old woman who underwent medical abortion with mifepristone and gemeprost and received codeine as pain-relief during the induction of abortion. She developed a severe acute necrotizing pancreatitis which required 14 days of intensive care. Other possible etiological factors, i.e. gallstone, alcohol intake and hyperlipidemia, were excluded.
The reported case of acute pancreatitis was most likely drug-induced.
Acute pancreatitis rarely complicates pregnancy. Acute pancreatitis complicated 1 in 3300 pregnancies at a large public hospital in Dallas, Texas , whereas in southern California 1 in 1500 women were affected . Other published reports cite incidences ranging widely from 1 in 1000 to 1 in 12,000 live births [3,4]. Although most pregnant women with acute pancreatitis have associated gallstones, less common causes such as trauma, drugs, and ethanol ingestion have also been reported [5,6]. We report the case of a woman who developed severe acute necrotizing pancreatitis that required 14 days of intensive care following medical abortion.
The patient was a pregnant gravida IV, para I, 34-year-old woman who due to severe malformation of the fetus underwent medical abortion. She was healthy, was not on any medication and had no known allergies. There was no history of alcohol or any other substance abuse. Previous interrupted pregnancies had been due to miscarriages in the first trimester and on one occasion medical abortion due to a diagnosed Turner's syndrome of the fetus.
A chorion villi sample during the present pregnancy had shown a normal female chromosomal constitution. However, repeated ultrasound examinations revealed poor fetal growth and a...